Blockade of fatty acid synthase induces ubiquitination and degradation of phosphatidylinositol-3 kinase signaling proteins in ovarian cancer
نویسندگان
چکیده
Katharina Tomek, Renate Wagner, Franz Varga, Christian F. Singer, Heidrun Karlic4, Thomas W. Grunt1,4 Signaling Networks Program, Division of Oncology, Department of Medicine I, Comprehensive Cancer Center, Medical University Vienna; Ludwig Boltzmann Institute of Osteology and 4th Medical Department, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Vienna; Department of Obstetrics/Gynecology, Comprehensive Cancer Center, Medical University Vienna; Ludwig Boltzmann Cluster Oncology, Medical University Vienna, Austria
منابع مشابه
Signaling and Regulation Blockade of Fatty Acid Synthase Induces Ubiquitination and Degradation of Phosphoinositide-3-Kinase Signaling Proteins in Ovarian Cancer
Aberrations within the phosphoinositide-3-kinase (PI3K) pathway occur in greater than 45% of ovarian carcinomas. The PI3K cascade transmits signals from ErbB receptors downstream to S6 and 4EBP1, which are involved in protein biosynthesis. Many ovarian carcinomas reveal hyperactivation of ErbB1 (epidermal growth factor receptor) or ErbB2 (HER2/neu).Unfortunately, the benefit of anti-ErbBdrugs i...
متن کاملBlockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer.
Aberrations within the phosphoinositide-3-kinase (PI3K) pathway occur in greater than 45% of ovarian carcinomas. The PI3K cascade transmits signals from ErbB receptors downstream to S6 and 4EBP1, which are involved in protein biosynthesis. Many ovarian carcinomas reveal hyperactivation of ErbB1 (epidermal growth factor receptor) or ErbB2 (HER2/neu). Unfortunately, the benefit of anti-ErbB drugs...
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Receptor-PI3K-mTORC1 signaling and fatty acid synthase (FASN)-regulated lipid biosynthesis harbor numerous drug targets and are molecularly connected. We hypothesize that unraveling the mechanisms of pathway cross-talk will be useful for designing novel co-targeting strategies for ovarian cancer (OC). The impact of receptor-PI3K-mTORC1 onto FASN is already well-characterized. However, reverse a...
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Somatostatin limits cell growth by inhibiting the proliferative activity of growth factor receptors. In this study, it is shown that in pituitary tumor cells, the somatostatin analogue octreotide produces its antiproliferative action by inducing the expression the tumor suppressor gene Zac1. ZAC/Zac1 induces cell cycle arrest and apoptosis and is highly expressed in normal pituitary, mammary, a...
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Essential fatty acids are not only energy-rich molecules; they are also an important component of the membrane bilayer and recently have been implicated in induction of fatty acid synthase and other genes. Using gene chip analysis, we have found that arachidonic acid, an omega-6 fatty acid, induced 11 genes that are regulated by nuclear factor-kappaB (NF-kappaB). We verified gene induction by o...
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تاریخ انتشار 2011